Minjie Wei, MD, PhD

CV for Minjie Wei, MD, PhD
Education
Ph.D. Sept.1993~July 1996, Graduate School, China Medical University.
M.D. Sept.1981~July 1986, School of Medicine, China Medicial University.
Work History
Research Associate, Mar. 2000~present, Department of Medicine, School of Medicine, University of Chicago, IL, US
Associate Professor, Dec.1998~Apr. 2000, Department of Molecular Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, China. Visiting Scholar, Sep.1998~Nov.1998, Department of Molecular Pharmacology, Sapporo Medical University, Sapporo, Japan.
Associate Professor, Apr.1995~Agu.1998, Department of Molecular Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Research Fellow, Mar.1994~Mar.1995, Department of Molecular Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
Assistant, Jan. 1994~Feb.1994, Department of Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Research Fellow, Agu.1993~Dec.1993, Department of Physiology, School of Medicine, Hokaido University, Sapporo, Japan. ·
Assistant, Jul. 1989~Jul.1993, Department of Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Research Major Field
1. The mechanism of promoter hypermethylation and BRCA1 and Estrogen receptor inactivation in sporadic breast cancer.
2. Study the roles of steroid hormone receptors and transcriptional factors in physiological and developmental process.
3. The Mechanism of Regulation on the Signal Transduction Pathway and Gene Expression in the Membrane Receptor.
Grants in China
1. "Studies on the Relation Between Signal Transduction Pathways in Calcium-induced and Expression of Tumor Suppression Gene in Endometrial Carcinoma Cells", supported by China National Nature Science Funding (Jan.2001~Dec.2003).
2. "Study on the siginal trasduction pathway of muscarinic receptor in uterus smooth muscle cells of human", supported by China National Nature Science Funding (Jan.1997~Dec.1999).
3. "Study on the function and regulation on the gene expression of ryanodine receptor of uterus smooth muscle cells of human", supported by China Ministry of Health Nature Science Funding for excellent younger (Jan.1997~Dec.1999).
4. "Study on the mechanism and inhibition of propofol on vascular smooth muscle", supported by State Education Commission of China (Jan.1996~ Dec.1998).
5. "Study on the muscarinic receptor in uterus smooth muscle of human", supported by National Nature Science Funding (Jan. 1993~Dec.1995).
Honors and Awards
1. Award of Ouderstanding Younger for Teaching and Reacher in Province of Liaoning. (2000)
2. Awarded by The Chinese Pharmacological Society and the Institut de Recherches Nationales Servier for Obtainning a Servier Younger Investigator Prize, 1998, (Franch).
3. Award of Science Advancement by Chinese Educational Committee, 1997, (China).
4. Award of Science Advancement by Educational Committee of Liaoning Pracince, 1996, (China).
5. The Excellent Thesis Award, The First Asia Microcirculational Institution, 1995, (Japan).
6. Award of Science Advancement by Educational Committee of Liaoning Province, 1994, (China).
Memberships
1996-1998, Member of Asia Pharmacologically Association.
1995-present, Chinese Nerve-Energy Pharmacological Society.
1992-present, Chinese Cardiovascular Pharmacological Society.
1989-present, China Pharmacological Society.
1989-present, Chinese Society for Cellular Biological.
Publications
1. Minjie Wei1, Tatyana Grushko1, Soma Das2, James Dignam3, Fitsum Hagos1, Lise Sveen1, James Fackenthal1 and Olufunmilayo I Olopade1. Hypermethylation of BRCA1 Promoter in Sporadic Breast Cancer: Comparison with BRCA 1 -Associated Hereditary Breast Cancer. (in preparation)
2. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002 Jul; 110(2):229-38
3. Li-Ping Cao, Merry Bolt, Minjie Wei, Michael D Sitrin, and Yan Chun Li. Regulation of Calbindin-D9K Expression by 1,25-dihydroxyvitamin D3 and Parathyroid Hormone in Primary Renal Tubular Cells. Arch Biochem Biophys. 2002 Apr 1;400(1):118-24.
4. WEI Min-Jie, Guo Ke-jun, Cong Hua, LI Zhi. Experimental study of carbacol induced IP3 and [Ca2+]i increase in cervix myometrium of human. Chinese Pharmacol Bulletin. 1999,15(3):229.
5. NIE Hua, Wei Min-Jie, GAO Ming-Qi, DING Xiao-Ping, LI Zhi. Effects of acetylcholine on inositol 1,4,5-triphosphate formation in the cervix myometrial cells of human. Acta Pharmacol Sin. 1999,20(7):659.
6. Wei Min-Jie, LI Zhi, CONG Hua. Mechanism of propofol inhibiting norepinephrine-induced elevation of intracellular free calcium in pulmonary artery smooth muscle cells of rat. Chinese J Pharmacol Toxicol. 1999,13(2):127.
7. Wei MJ, Jin WB, Li Z, Guan FL, Sheng ZR. Effects of propofol on rat systemic and pulmonary circulation. J China Med Univer, 1998;27(5):445.
8. WEI Min-Jie, NIE Hua, WANG Hong-Mei, LI Zhi, SHENG Zhuo-Ren. Inhibition of propofol on IP3 increase by norepinephrine, 5-hydroxytryp-tamine and A23187-induced in aortic smooth muscle cells of rats. Acta Pharmacol Sin. 1998;19(2):187.
9. MJ wei, F Shintani,S Kanba, G Yagi, M Asai, R Kato, T Nakaki. Endothelium- depeddent and -independent vasoactive action of a Japanene Kampo medicine, Saiko-ka-ryukotsu-borei-to. Biomed & Pharmacother, 1997;51:39.
10. Wei Min-Jie, Li Zhi, Wang Jun-Ke, Sheng Zhuo-Ren, Wang Hong-Mei. Mechanism of inhibition of propofol on intracellular calcium increase in aortic smooth muscle cells. Chin J Anesthesiol, 1997;17(11):676.
11. Wei Min-Jie, Sheng Zhuo-Ren, Li Zhi, Nie Hua, Wang Jun-Ke, Inhibition of propofol on IP3 formation in rat pulmonary artery smooth muscle. Natl Med J China, 1997;77(11):864.
12. LI Z, Zhang Q, Wei M, Cong H, Ouda H, Odajima K, Takemura H. High responsiveness of cytosolic free calcium concentration to angiotensin II in cultured pulmonary arterial myocytes from pulmonary hypertensive rats. Res Commun Mol Pathol Pharmacol, 1997 Aug;97(2):125.
13. Z Li, MJ Wei, QL Zhang. Detection of Ca2+ level in primarily cultured smooth muscle cell from chronic hypoxic pulmonary hypertension rat. J Histochem Cellchem, 1997;6(5):250.
14. Wei MJ, Guo ZD, Nie H, Cong H, Li Z, Shang T. The study of muscarinic receptor subtypes in isthmic smooth muscle of nonpregnant human Uterus(II). J China Med Univer, 1996;25(5):447.
15. GUO ZD, MJ Wei, Cong H, Zhao SH, Li Z. Distribution of muscarinic receptor of different affinities in smooth muscle of human non-pregnant uterus. J China Med Univer, 1996;25(5): 449.
16. Nie H, Wei MJ, GUO ZD,Shang T, Cong H, Li Z. Identification of human pregnancy uterus cervix smooth muscle muscarinic receptor and inosotol 1,4,5-trisphosphate. J China Med Univer, 1996;25(5): 452.
17. Wei MJ, Koyama T, Zhao NC, Li Z. Influence of tetramethylpyrazine on pulmonary microcirculation in anesthetixed billfrogs. Chin J Pharmacol Toxicol, 1996;10(3):193.
18. Wei MJ, Guo ZD, Zhang QL, Cong H, Li Z, Shang T. The study of muscarinic receptor subtypes in isthmic smooth muscle of nonpregnant human Uterus. J China Med Univer, 1996;25(2):118.
19. MJ Wei, T Nakaki, F Shintani,S Kanba, G Yagi, M Asai, R Kato. Dual effects of TJ-12 on contraction of rat thoracic aorta elicited by norepine-phrine, serotonin and high potassium. J Japan Pharmacol, 1995;67(1):180P.
20. Wei MJ, Wang HL, Zhao NC. Effects of chinese medicine, ligustrazine on the vascular tone and PGI2 production in rat pulmonary artery, and on the pulmonary microcirculation in bullforg. Prog Microcircul Res, 1994;20(1):77.
21. MJ Wei, XH Zhang, NC Zhao. Effects of QH-I and QH-M on ioslated pulmonary arteries of rabbits. Zhong Cao Yao, 1994;25(3):137.
22. Zhang XH, Zhao NC, Wei MJ. Effect of 8-Methoxypsoralen on Smooth Muscle of Rabbit Pulmonary Artery. J China Med Univer, 1995;24(2):135.
23. MJ Wei, HL Wang, NC Zhao. Influence of ligustrazine on vascular tone and PGI2 biosynthesis in ioslated rat pulmonary arteries. J China Med Univer, 1991;20(2):85.
24. MJ Wei, XH Zhang, NC Zhao. Effect of "Qian-Hu" on noradrenaline and potassium-induced contraction of rabbit pulmonary arteries. Chin J Med Sci, 1991;6(3):60.