Research Studies

The University of Chicago Cancer Risk Clinic is participating in a number of research studies. If you would like more information, or are interested in participating, please call 773-702-4749.

Ovarian Cancer Screening in High Risk Women
Inactivation and Breast Cancer Risk
Molecular Analysis of Solid Tumors/Tissues
Mammographic Density & Risk of Breast Cancer
Molecular Genetics of Aggressive Breast Cancer

Ovarian Cancer Screening in High Risk Women
The purpose of this project is to establish a standardized screening program for women at high risk for ovarian cancer seen in our medical center. Through this multidisciplinary program, we plan to establish a standardized screening program and determine its associated cost. We also plan to analyze the impact that screening will have on the quality of life of these women. Lastly, we will establish a database that will include patient specimens and radiographic materials on which to draw for future studies.

Inactivation and Breast Cancer Risk
This study is researching breast and ovarian cancer in African-American families who have a personal or family history of these forms of cancer. This research is done in conjunction with the University of Utah and is federally funded by the National Institutes of Health, National Cancer Institute. The purpose of this research study is to increase our understanding of the genetic, environmental and medical risk factors associated with breast and ovarian cancer. We are studying individuals with these cancers and their relatives to identify factors which may affect the risk of breast and/or ovarian cancer. These factors may be identified through analysis of questionnaire data and DNA samples (extracted from blood). If people at greatest risk of developing breast or ovarian cancer were identified early, actions can be taken in hopes of preventing or better controlling the disease. Download our information sheet about the study.

Molecular Analysis of Solid Tumors/Tissues
The purpose of this study is to attempt to determine the incidence of certain biochemical and genetic changes in breast and ovarian cancers. It is believed that these changes lead to the development or spread of these cancers. In this study, participants who are planning on have tissue removed from them body will be asked to donate some of the removed tissue (breast or ovaries) for research purposes only. The tissue used for research will not require them to undergo any additional procedures and will not affect the accuracy of any routine pathology tests. The samples we obtain will be used for performing special research tests and, in some cases; these tests may be performed years later. These tests may provide additional information that will be helpful in understanding the disease or how patients respond to treatment.

Mammographic Density & Risk of Breast Cancer
This study is identifying whether the mammographic appearance of the breast is associated with the development of breast cancer in women from high-risk families. Mammogram films will be collected and evaluated for breast density and returned to the participant or the originating hospital. Mammograms will be evaluated for breast density and not for the presence of breast cancer. (IRB-approved)

Molecular Genetics of Aggressive Breast Cancer
This research proposal is focusing on causes of breast cancer in young women. We hope to better understand this complex disease caused by genetic changes that progress through different molecular pathways, and develop improved methods for identifying women at risk who could benefit from novel prevention and treatment strategies. This study represents an integrated attempt to translate the recent advances in genetics to the benefit of women who are at risk of developing an aggressive form of breast cancer at a young age. The accurate definition of genetic risks for young women will eventually lead to better clinical risk assessment and the development of more effective strategies for prevention, early detection and treatment of breast cancer for all women. Study participants will donate a sample of blood for research and complete study questionnaires. Download our information sheet about the study.

If you are interested in participating in any of these studies call the Cancer Risk Clinic for more information at 773-702-4749.